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Jens Marc Titze
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Associate Professor, Cardiovascular and Metabolic Disorders Program

Duke-National University of Singapore Medical School 

Professor of Medicine, Duke University School of Medicine, Durham, NC, USA

Professor for Electrolyte and Circulation Research, University Clinic Erlangen, Germany

Adjunct A/Prof A*STAR Skin Research Institute of Singapore (SRIS)

Jens Titze is a clinician-scientist. He works as an Associate Professor at Duke-NUS Singapore and atA*STAR’s Skin Research Institute of Singapore (primary affiliations), at Duke University School ofMedicine in Durham, USA, and at his Alma Mater, the University Clinical of Erlangen, Germany. Jens isan elected member of the American Society of Clinical Investigation and of the European Academy ofSciences and Arts. His research is currently funded by the National Institutes of Health, the AmericanHeart Association, the German Research Council, the Federal Ministry of Economy and Technology inGermany, and others.

As a medical student in Berlin, Jens was introduced to the idea that sodium might be stored in the body,which pretty much contradicted what he had been taught at school. He decided to focus his studies onthis area. 25 years later, his research has established that both animals and humans store large amountsof sodium in their tissues as they age, that this sodium storage is coupled with disease, and that dietarysalt loading activates an adaptive network in the kidney, muscle and liver, which burn calories to excretesalt. These observations challenge some of what is currently held as pillars of physiology. His worksuggests that there is still a lot to learn on the effect of sodium chloride on the body, and that it is timeto “rethink salt”.

His research teams work collaboratively in the clinical research and molecular physiology researchdomain. The molecular physiology projects headed by his junior research associates focus on how thekidney, the liver, skeletal muscle, the skin, and the immune system residing in the lymphaticsinterconnect into a physiological network that regulates salt and water homeostasis. The patient-oriented projects headed by his junior clinician research associates transfer these findings into clinicalpractice, relying on deep clinical phenotyping with innovative methods such as 23NaMRI imagingstudies for non-invasive detection and quantification of otherwise hidden sodium stores in humans.

This interdisciplinary science approach has resulted in new research avenues for current understandingof the underlying cause of diseases of the aging organism, such as arterial hypertension, diabetesmellitus, autoimmune disease and host defence, and muscle and bone loss.


Attendance records:1

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The academic assignments are as follows
Date (UTC+8) Time (UTC+8) Local Time Hall Session Role Talk Title
2022-06-18 10:15-10:45 2022-06-18,10:15-10:45Hall 1

Plenary Session VI

Speaker Rethinking Salt and Water Metabolism